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A cleanroom technician in full sterile garments mops a glossy epoxy floor inside a controlled environment. Stainless steel storage cabinets line the background, with seamless wall panels and a HEPA-filtered ceiling overhead.

SOPs for Facility Maintenance, Cleaning and Sanitization

This is Chapter 4 of Valutek's Technical Paper Series:
Standard Operating Procedures for Controlled Environments
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Overview

Cleanrooms demand a meticulously defined and executed cleaning regimen. SOPs for cleaning and sanitizing controlled environments are essential to ensure the continuous removal of viable and non-viable particulates while maintaining regulatory compliance and operational consistency.

By the end of Chapter 4, readers will understand how to:

  • Define cleaning frequencies and task sequences based on ISO classification

  • Select compatible cleanroom wipers, mops, and chemistries for various surfaces

  • Write clear, step-by-step SOPs that standardize procedures and minimize contamination risks

  • Incorporate validation, auditing, and visual inspection techniques to verify outcomes

“Having documented and scheduled cleaning that is conducted according to the SOP maintains the integrity of the controlled environment and decreases the risk of product contamination.”

 

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Continue deepening your understanding of SOPs for controlled environments:
Jan Eudy is a cleanroom/contamination control and microbiological subject matter expert with more than 30 years of industry experience in semiconductor, microelectronics, pharmaceutical, biopharmaceutical, medical device, food manufacturing, compounding pharmacies, aerospace, and automotive. As the corporate quality assurance manager for Cintas Corp., Jan oversaw research and development, directed the quality system and ISO registration at all cleanroom locations, and supported validation and sterile services. During her time with the company, Jan also implemented and maintained the HACCP risk management program at all Cintas industrial laundries. She is also a Past President and Fellow of the Institute for Environmental Sciences and Technology (IEST).

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